Association of interleukin-1 gene variations with moderate to severe chronic periodontitis in multiple ethnicities.

ABSTRACT:

Background and objective

Genetic markers associated with disease are often non-functional and generally tag one or more functional "causative" variants in linkage disequilibrium. Markers may not show tight linkage to the causative variants across multiple ethnicities due to evolutionary divergence, and therefore may not be informative across different population groups. Validated markers of disease suggest causative variants exist in the gene and, if the causative variants can be identified, it is reasonable to hypothesize that such variants will be informative across diverse populations. The aim of this study was to test that hypothesis using functional Interleukin-1 (IL-1) gene variations across multiple ethnic populations to replace the non-functional markers originally associat

SUBMITTER: Wu X 

PROVIDER: S-EPMC4183738 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature