Prenatal drinking-water exposure to tetrachloroethylene and ischemic placental disease: a retrospective cohort study.

ABSTRACT:

Background

Prenatal drinking water exposure to tetrachloroethylene (PCE) has been previously related to intrauterine growth restriction and stillbirth. Pathophysiologic and epidemiologic evidence linking these outcomes to certain other pregnancy complications, including placental abruption, preeclampsia, and small-for-gestational-age (SGA) (i.e., ischemic placental diseases), suggests that PCE exposure may also be associated with these events. We examined whether prenatal exposure to PCE-contaminated drinking water was associated with overall or individual ischemic placental diseases.

Methods

Using a retrospective cohort design, we compared 1,091 PCE-exposed and 1,019 unexposed pregnancies from 1,766 Cape Cod, Massachusetts women. Exposure between 1969 and 1990 was estimated

SUBMITTER: Carwile JL 

PROVIDER: S-EPMC4183765 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature