Multicenter closed-loop/hybrid meal bolus insulin delivery with type 1 diabetes.

ABSTRACT:

Background

This study evaluated meal bolus insulin delivery strategies and associated postprandial glucose control while using an artificial pancreas (AP) system.

Subjects and methods

This study was a multicenter trial in 53 patients, 12-65 years of age, with type 1 diabetes for at least 1 year and use of continuous subcutaneous insulin infusion for at least 6 months. Four different insulin bolus strategies were assessed: standard bolus delivered with meal (n=51), standard bolus delivered 15 min prior to meal (n=40), over-bolus of 30% delivered with meal (n=40), and bolus purposely omitted (n=46). Meal carbohydrate (CHO) intake was 1 g of CHO/kg of body weight up to a maximum of 100 g for the first three strategies or up to a maximum of 50 g for strategy 4.

Results

On

SUBMITTER: Chase HP 

PROVIDER: S-EPMC4183919 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature