Arginine-directed glycation and decreased HDL plasma concentration and functionality.

ABSTRACT:

Background/objectives

Decreased plasma concentration of high-density lipoprotein cholesterol (HDL-C) is a risk factor linked to increased risk of cardiovascular disease (CVD). Decreased anti-atherogenic properties of HDL are also implicated in increased CVD risk. The cause is unknown but has been linked to impaired glucose tolerance. The aim of this study was to quantify the modification of HDL by methylglyoxal and related dicarbonyls in healthy people and patients with type 2 diabetes characterise structural, functional and physiological consequences of the modification and predict the importance in high CVD risk groups.

Subjects/methods

Major fractions of HDL, HDL2 and HDL3 were isolated from healthy human subjects and patients with type 2 diabetes and fractions modified b

SUBMITTER: Godfrey L 

PROVIDER: S-EPMC4183972 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature