Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5.

ABSTRACT: Metabolic dysfunction in skeletal muscle is a major contributor to the development of type 2 diabetes. Endurance exercise training has long been established as an effective means to directly restore skeletal muscle glucose and lipid uptake and metabolism. However, in addition to the direct effects of skeletal muscle on glucose and lipids, there is renewed interest in the ability of skeletal muscle to coordinate metabolic activity of other tissues, such as adipose tissue and liver. The purpose of this study was to examine the effects of endurance exercise on the expression level of two novel muscle-derived secreted factors, or myokines, Myonectin and Fibronectin type III domain containing 5 (FNDC5), the precursor for Irisin. Methods. We performed immunoblot analysis and quantitative real-ti

SUBMITTER: Peterson JM 

PROVIDER: S-EPMC4184026 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature