Dietary sodium restriction decreases insulin secretion without affecting insulin sensitivity in humans.

ABSTRACT:

Context

Interruption of the renin-angiotensin-aldosterone system prevents incident diabetes in high-risk individuals, although the mechanism remains unclear.

Objective

To test the hypothesis that activation of the endogenous renin-angiotensin-aldosterone system or exogenous aldosterone impairs insulin secretion in humans.

Design

We conducted a randomized, blinded crossover study of aldosterone vs vehicle and compared the effects of a low-sodium versus a high-sodium diet.

Setting

Academic clinical research center.

Participants

Healthy, nondiabetic, normotensive volunteers.

Interventions

Infusion of exogenous aldosterone (0.7 μg/kg/h for 12.5 h) or vehicle during low or high sodium intake. Low sodium (20 mmol/d; n = 12) vs high sodium (160 mmol/d; n

SUBMITTER: Luther JM 

PROVIDER: S-EPMC4184066 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature