Extensive drug resistance acquired during treatment of multidrug-resistant tuberculosis.

ABSTRACT:

Background

Increasing access to drugs for the treatment of multidrug-resistant (MDR) tuberculosis is crucial but could lead to increasing resistance to these same drugs. In 2000, the international Green Light Committee (GLC) initiative began to increase access while attempting to prevent acquired resistance.

Methods

To assess the GLC's impact, we followed adults with pulmonary MDR tuberculosis from the start to the end of treatment with monthly sputum cultures, drug susceptibility testing, and genotyping. We compared the frequency and predictors of acquired resistance to second-line drugs (SLDs) in 9 countries that volunteered to participate, 5 countries that met GLC criteria, and 4 countries that did not apply to the GLC.

Results

In total, 832 subjects were enrolled.

SUBMITTER: Cegielski JP 

PROVIDER: S-EPMC4184341 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature