Plasma profiling reveals three proteins associated to amyotrophic lateral sclerosis.

ABSTRACT:

Objective

Amyotrophic lateral sclerosis (ALS) is the most common adult motor neuron disease leading to muscular paralysis and death within 3-5 years from onset. Currently, there are no reliable and sensitive markers able to substantially shorten the diagnosis delay. The objective of the study was to analyze a large number of proteins in plasma from patients with various clinical phenotypes of ALS in search for novel proteins or protein profiles that could serve as potential indicators of disease.

Methods

Affinity proteomics in the form of antibody suspension bead arrays were applied to profile plasma samples from 367 ALS patients and 101 controls. The plasma protein content was directly labeled and protein profiles obtained using 352 antibodies from the Human Protein Atlas t

SUBMITTER: Haggmark A 

PROVIDER: S-EPMC4184557 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature