Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity.

ABSTRACT:

Objectives

Diabetes leads to cognitive impairment and is associated with age-related neurodegenerative diseases including Alzheimer's disease (AD). Thus, understanding diabetes-induced alterations in brain function is important for developing early interventions for neurodegeneration. Low-capacity runner (LCR) rats are obese and manifest metabolic risk factors resembling human "impaired glucose tolerance" or metabolic syndrome. We examined hippocampal function in aged LCR rats compared to their high-capacity runner (HCR) rat counterparts.

Methods

Hippocampal function was examined using proton magnetic resonance spectroscopy and imaging, unbiased stereology analysis, and a Y maze. Changes in the mitochondrial respiratory chain function and levels of hyperphosphorylated tau an

SUBMITTER: Choi J 

PROVIDER: S-EPMC4184561 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature