Highly adaptable triple-negative breast cancer cells as a functional model for testing anticancer agents.

ABSTRACT: A major obstacle in developing effective therapies against solid tumors stems from an inability to adequately model the rare subpopulation of panresistant cancer cells that may often drive the disease. We describe a strategy for optimally modeling highly abnormal and highly adaptable human triple-negative breast cancer cells, and evaluating therapies for their ability to eradicate such cells. To overcome the shortcomings often associated with cell culture models, we incorporated several features in our model including a selection of highly adaptable cancer cells based on their ability to survive a metabolic challenge. We have previously shown that metabolically adaptable cancer cells efficiently metastasize to multiple organs in nude mice. Here we show that the cancer cells modeled in our

SUBMITTER: Singh B 

PROVIDER: S-EPMC4184880 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature