Common DNA methylation alterations in multiple brain regions in autism.

ABSTRACT: Autism spectrum disorders (ASD) are increasingly common neurodevelopmental disorders defined clinically by a triad of features including impairment in social interaction, impairment in communication in social situations and restricted and repetitive patterns of behavior and interests, with considerable phenotypic heterogeneity among individuals. Although heritability estimates for ASD are high, conventional genetic-based efforts to identify genes involved in ASD have yielded only few reproducible candidate genes that account for only a small proportion of ASDs. There is mounting evidence to suggest environmental and epigenetic factors play a stronger role in the etiology of ASD than previously thought. To begin to understand the contribution of epigenetics to ASD, we have examined DNA meth

SUBMITTER: Ladd-Acosta C 

PROVIDER: S-EPMC4184909 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature