Androgen receptor CAG repeat polymorphism and risk of TMPRSS2:ERG-positive prostate cancer.

ABSTRACT:

Background

The androgen receptor (AR) is an essential gene in prostate cancer pathogenesis and progression. Genetic variation in AR exists, including a polymorphic CAG repeat sequence that is inversely associated with transcriptional activity. Experimental data suggest that heightened AR activity facilitates formation of TMPRSS2:ERG, a gene fusion present in approximately 50% of tumors of patients with prostate cancer.

Methods

We undertook a nested case-control study to investigate the hypothesis that shorter CAG repeat length would be associated with prostate cancer risk defined by TMPRSS2:ERG status. The study included 291 men with prostate cancer (147 ERG-positive) and 1,221 cancer-free controls. ORs and 95% confidence intervals (CI) were calculated using logistic regress

SUBMITTER: Yoo S 

PROVIDER: S-EPMC4184923 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature