Clinical implications of phosphorylated STAT3 expression in De Novo diffuse large B-cell lymphoma.

ABSTRACT:

Purpose

Activated signal transducer and activator of transcription 3 (STAT3) regulates tumor growth, invasion, cell proliferation, angiogenesis, immune response, and survival. Data regarding expression of phosphorylated (activated) STAT3 in diffuse large B-cell lymphoma (DLBCL) and the impact of phosphorylated STAT3 (pSTAT3) on prognosis are limited.

Experimental design

We evaluated expression of pSTAT3 in de novo DLBCL using immunohistochemistry, gene expression profiling (GEP), and gene set enrichment analysis (GSEA). Results were analyzed in correlation with cell-of-origin (COO), critical lymphoma biomarkers, and genetic translocations.

Results

pSTAT3 expression was observed in 16% of DLBCL and was associated with advanced stage, multiple extranodal sites of involv

SUBMITTER: Ok CY 

PROVIDER: S-EPMC4184926 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature