Forward and backward wave morphology and central pressure augmentation in men and women in the Framingham Heart Study.

ABSTRACT: Central pressure augmentation is associated with greater backward wave amplitude and shorter transit time and is higher in women for reasons only partially elucidated. Augmentation also is affected by left ventricular function and shapes of the forward and backward waves. The goal of this study was to examine the relative contributions of forward and backward wave morphology to central pressure augmentation in men and women. From noninvasive measurements of central pressure and flow in 7437 participants (4036 women) aged from 19 to 90 years (mean age, 51 years), we calculated several variables: augmentation index, backward wave arrival time, reflection factor, forward wave amplitude, forward wave peak width, and slope of the backward wave upstroke. Linear regression models for augmentation

SUBMITTER: Torjesen AA 

PROVIDER: S-EPMC4184952 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature