Assisted hatching and intracytoplasmic sperm injection are not associated with improved outcomes in assisted reproduction cycles for diminished ovarian reserve: an analysis of cycles in the United States from 2004 to 2011.

ABSTRACT:

Objective

To investigate the impact of intracytoplasmic sperm injection (ICSI) and assisted hatching (AH) on assisted reproductive technology (ART) outcomes in initial cycles with diminished ovarian reserve (DOR) as the primary diagnosis.

Design

Retrospective cohort study of cycles from the Society for Assisted Reproductive Technology (SART) Clinic Outcome Reporting System database.

Setting

Not applicable.

Patient(s)

A total of 422,949 fresh, nondonor, initial ART cycles of which 8,597 were diagnosed with only elevated FSH and 38,926 were diagnosed with only DOR according to the SART DOR categorization.

Intervention(s)

None.

Main outcome measure(s)

Live birth and clinical pregnancy rates.

Result(s)

ICSI and AH were associated with diminishe

SUBMITTER: Butts SF 

PROVIDER: S-EPMC4184996 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature