A randomized controlled trial of intranasal ketamine in major depressive disorder.

ABSTRACT:

Background

The N-methyl-D-aspartate glutamate receptor antagonist ketamine, delivered via an intravenous route, has shown rapid antidepressant effects in patients with treatment-resistant depression. The current study was designed to test the safety, tolerability, and efficacy of intranasal ketamine in patients with depression who had failed at least one prior antidepressant trial.

Methods

In a randomized, double-blind, crossover study, 20 patients with major depression were randomly assigned, and 18 completed 2 treatment days with intranasal ketamine hydrochloride (50 mg) or saline solution. The primary efficacy outcome measure was change in depression severity 24 hours after ketamine or placebo, measured using the Montgomery-Åsberg Depression Rating Scale. Secondary outcom

SUBMITTER: Lapidus KA 

PROVIDER: S-EPMC4185009 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature