Widespread signals of convergent adaptation to high altitude in Asia and america.

ABSTRACT: Living at high altitude is one of the most difficult challenges that humans had to cope with during their evolution. Whereas several genomic studies have revealed some of the genetic bases of adaptations in Tibetan, Andean, and Ethiopian populations, relatively little evidence of convergent evolution to altitude in different continents has accumulated. This lack of evidence can be due to truly different evolutionary responses, but it can also be due to the low power of former studies that have mainly focused on populations from a single geographical region or performed separate analyses on multiple pairs of populations to avoid problems linked to shared histories between some populations. We introduce here a hierarchical Bayesian method to detect local adaptation that can deal with complex

SUBMITTER: Foll M 

PROVIDER: S-EPMC4185124 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature