Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates.

ABSTRACT: The development of efficient methods for accessing fluorinated functional groups is desirable. Herein, we report a two-step method that utilizes catalytic Cu for the decarboxylative trifluoromethylation of propargyl bromodifluoroacetates. This protocol affords a mixture of propargyl trifluoromethanes and trifluoromethyl allenes.

SUBMITTER: Ambler BR 

PROVIDER: S-EPMC4185158 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature