Erythrocyte saturated fatty acids and systemic inflammation in adults.

ABSTRACT:

Objective

The role of saturated fatty acids (SFAs) in chronic disease remains controversial; inflammation is one pathway by which SFAs influence the risk for chronic disease. The aim of this study was to investigate the associations between red blood cell (RBC) phospholipid SFAs and systemic inflammation.

Methods

As part of a randomized controlled trial, we measured RBC phospholipid FA composition in 55 generally healthy adults twice at 3-mo intervals. We estimated associations of RBC total SFAs and two major SFA subtypes, palmitic and stearic acids, with C-reactive protein (CRP), interleukin (IL)-6, white blood count (WBC), and a composite inflammation measure using generalized estimating equations in multivariable FA substitution models.

Results

Mean (±SD) SFA level

SUBMITTER: Mu L 

PROVIDER: S-EPMC4185280 | biostudies-literature | 2014 Nov-Dec

REPOSITORIES: biostudies-literature