P04.202-D FLUORESCENCE DIFFERENCE GEL ELECTROPHORESIS (DIGE) AND MASS SPECTROMETRY ANALYSIS IN EPENDIMOMAS: PRELIMINARY DATA

ABSTRACT: Despite the histological similarity of ependymomas from throughout the neuroaxis, the disease comprises multiple entities, depending on site of origin (spinal cord, posterior fossa and supratentorial) and patient age (children versus adults). Although detailed histological examination may identify important prognostic factors, their strength varies between subsets. Clinically, ependymomas remain an enigma to neuro-oncologists and neurosurgeons. Proteomic data on ependimomas are scant but a more detailed insight may complement cytogenetic and gene expression data in the effort to achieve a robust classification system of pediatric and adult ependymomas as a base for a molecular based therapy. RNA, DNA and proteins were extracted from 14 selected ependimomas. Proteins were analyzed with a 2-

SUBMITTER: Morra I 

PROVIDER: S-EPMC4185497 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature