Hydroxyethyl starch as an effective methotrexate carrier in anticancer therapy.

ABSTRACT: At present, effective anticancer therapy remains one of the most challenging tasks facing the scientific community. A major limitation to most conventional low-molecular weight anticancer chemotherapeutics is their unfavourable uptake by healthy tissue, fast metabolism and lack of tumour cell selectivity. One way to solve this problem is the application of hybrid nanoparticles containing widely known therapeutic substances. This study was performed with the aim of investigating the potential of use hydroxyethyl starch (HES) as a high-molecular weight carrier for anticancer drug (methotrexate, MTX). HES-MTX conjugates were characterized in terms of MTX content, hydrodynamic size, zeta potential, and drug release kinetics. In vitro biological characteristics were determined using different c

SUBMITTER: Goszczynski TM 

PROVIDER: S-EPMC4186415 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature