Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence.

ABSTRACT:

Background

Filaggrin is an epidermal protein that has a role in skin barrier function. Filaggrin loss-of-function (FLG-LOF) mutations are a significant risk factor for eczema and atopy, but their association with food allergy (FA) is less clear.

Objective

We explored the longitudinal relationship between 3 common FLG-LOF mutations and FA using the Isle of Wight birth cohort.

Methods

FA diagnosis was based on recognized allergic reactions within 4 hours after exposure to known food allergens. Food allergen sensitization (FAS) was identified by using skin prick tests conducted between 1 and 18 years of age to a range of food allergens. Three FLG mutations were genotyped in 1150 (79%) of 1456 children. The temporal relationships between FA, FAS, and eczema in children wi

SUBMITTER: Venkataraman D 

PROVIDER: S-EPMC4186905 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature