Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma.

ABSTRACT:

Background and objective

Environmental or lifestyle exposures in utero may influence the development of childhood asthma. In this meta-analysis, we aimed to assess whether maternal obesity in pregnancy (MOP) or increased maternal gestational weight gain (GWG) increased the risk of asthma in offspring.

Methods

We included all observational studies published until October 2013 in PubMed, Embase, CINAHL, Scopus, The Cochrane Database, and Ovid. Random effects models with inverse variance weights were used to calculate pooled risk estimates.

Results

Fourteen studies were included (N = 108 321 mother-child pairs). Twelve studies reported maternal obesity, and 5 reported GWG. Age of children was 14 months to 16 years. MOP was associated with higher odds of asthma or wheeze

SUBMITTER: Forno E 

PROVIDER: S-EPMC4187236 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature