Distinct regions of NLRP1B are required to respond to anthrax lethal toxin and metabolic inhibition.

ABSTRACT: Pattern recognition receptors monitor for signs of infection or cellular dysfunction and respond to these events by initiating an immune response. NLRP1B is a receptor that upon activation recruits multiple copies of procaspase-1, which promotes cytokine processing and a proinflammatory form of cell death termed pyroptosis. NLRP1B detects anthrax lethal toxin when the toxin cleaves an amino-terminal fragment from the protein. In addition, NLRP1B is activated when cells are deprived of glucose or treated with metabolic inhibitors, but the mechanism by which the resulting reduction in cytosolic ATP is sensed by NLRP1B is unknown. Here, we addressed whether these two activating signals of NLRP1B converge on a common sensing system. We show that an NLRP1B mutant lacking the amino-terminal regi

SUBMITTER: Neiman-Zenevich J 

PROVIDER: S-EPMC4187829 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature