Assessing bias in osteoarthritis trials included in Cochrane reviews: protocol for a meta-epidemiological study.

ABSTRACT:

Introduction

The validity of systematic reviews and meta-analysis depends on methodological quality and unbiased dissemination of trials. Our objective is to evaluate the association of estimates of treatment effects with different bias-related study characteristics in meta-analyses of interventions used for treating pain in osteoarthritis (OA). From the findings, we hope to consolidate guidance on interpreting OA trials in systematic reviews based on empirical evidence from Cochrane reviews.

Methods and analysis

Only systematic reviews that compare experimental interventions with sham, placebo or no intervention control will be considered eligible. Bias will be assessed with the risk of bias tool, used according to the Cochrane Collaboration's recommendations. Furthermore,

SUBMITTER: Hansen JB 

PROVIDER: S-EPMC4187994 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature