Sleep spindle deficits in antipsychotic-naive early course schizophrenia and in non-psychotic first-degree relatives.

ABSTRACT: INTRODUCTION:Chronic medicated patients with schizophrenia have marked reductions in sleep spindle activity and a correlated deficit in sleep-dependent memory consolidation. Using archival data, we investigated whether antipsychotic-naïve early course patients with schizophrenia and young non-psychotic first-degree relatives of patients with schizophrenia also show reduced sleep spindle activity and whether spindle activity correlates with cognitive function and symptoms. METHOD:Sleep spindles during Stage 2 sleep were compared in antipsychotic-naïve adults newly diagnosed with psychosis, young non-psychotic first-degree relatives of schizophrenia patients and two samples of healthy controls matched to the patients and relatives. The relations of spindle parameters with cognitive measures

SUBMITTER: Manoach DS 

PROVIDER: S-EPMC4188028 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature