Prediction of acute respiratory disease in current and former smokers with and without COPD.

ABSTRACT:

Background

The risk factors for acute episodes of respiratory disease in current and former smokers who do not have COPD are unknown.

Methods

Eight thousand two hundred forty-six non-Hispanic white and black current and former smokers in the Genetic Epidemiology of COPD (COPDGene) cohort had longitudinal follow-up (LFU) every 6 months to determine acute respiratory episodes requiring antibiotics or systemic corticosteroids, an ED visit, or hospitalization. Negative binomial regression was used to determine the factors associated with acute respiratory episodes. A Cox proportional hazards model was used to determine adjusted hazard ratios (HRs) for time to first episode and an acute episode of respiratory disease risk score.

Results

At enrollment, 4,442 subjects did no

SUBMITTER: Bowler RP 

PROVIDER: S-EPMC4188150 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature