Allodynia and descending pain modulation in migraine: a resting state functional connectivity analysis.

ABSTRACT:

Objective

Most migraineurs develop cutaneous allodynia during migraines, and many have cutaneous sensitization between attacks. Atypical pain modulation via the descending pain system may contribute to this sensitization and allodynia. The objective of this study was to test the hypothesis that compared with non-allodynic migraineurs, allodynic migraineurs have atypical periaqueductal gray (PAG) and nucleus cuneiformis (NCF) resting-state functional connectivity (rs-fc) with other pain processing regions.

Design

Ten minutes resting-state blood-oxygen-level-dependent data were collected from 38 adult migraineurs and 20 controls. Seed-based analyses compared whole-brain rs-fc with PAG and with NCF in migraineurs with severe ictal allodynia (N = 8) to migraineurs with no ictal

SUBMITTER: Schwedt TJ 

PROVIDER: S-EPMC4188437 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature