Peyer's patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy.

ABSTRACT:

Background and objective

To improve the efficacy and safety of tolerance induction for food allergies, identifying the tissues responsible for inducing intestinal inflammation and subsequent oral tolerance is important. We used OVA23-3 mice, which express an ovalbumin-specific T-cell receptor, to elucidate the roles of local and systemic immune tissues in intestinal inflammation.

Methods and results

OVA23-3 mice developed marked enteropathy after consuming a diet containing egg white (EW diet) for 10 days but overcame the enteropathy (despite continued moderate inflammation) after receiving EW diet for a total of 28 days. Injecting mice with anti-IL-4 antibody or cyclosporine A confirmed the involvement of Th2 cells in the development of the enteropathy. To assess the indivi

SUBMITTER: Nakajima-Adachi H 

PROVIDER: S-EPMC4188560 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature