Cost-effectiveness of HIV drug resistance testing to inform switching to second line antiretroviral therapy in low income settings.

ABSTRACT:

Background

To guide future need for cheap resistance tests for use in low income settings, we assessed cost-effectiveness of drug resistance testing as part of monitoring of people on first line ART - with switching from first to second line ART being conditional on NNRTI drug resistance mutations being identified.

Methods

An individual level simulation model of HIV transmission, progression and the effect of ART which accounts for adherence and resistance development was used to compare outcomes of various potential monitoring strategies in a typical low income setting in sub-Saharan Africa. Underlying monitoring strategies considered were based on clinical disease, CD4 count or viral load. Within each we considered a strategy in which no further measures are performed, one

SUBMITTER: Phillips A 

PROVIDER: S-EPMC4188574 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature