Statin use and risk of hepatocellular carcinoma in a U.S. population.

ABSTRACT:

Purpose

Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are medications widely prescribed to reduce cholesterol levels. Observational studies in high-risk populations, mostly in Asia, have suggested that statins are associated with a reduced risk of hepatocellular carcinoma (HCC). The current study sought to evaluate the association of statin use and HCC in a U.S.-based, low-risk, general population.

Methods

A nested case-control study was conducted among members of the Health Alliance Plan HMO of the Henry Ford Health System enrolled between 1999 and 2010. Electronic pharmacy records of statin use were compared among tumor registry-confirmed cases of HCC (n=94) and controls (n=468) matched on age, sex, diagnosis date, and length of HMO enrolment.

Res

SUBMITTER: McGlynn KA 

PROVIDER: S-EPMC4188715 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature