Risk of primary liver cancer associated with gallstones and cholecystectomy: a meta-analysis.

ABSTRACT:

Background

Recent epidemiological evidence points to an association between gallstones or cholecystectomy and the incidence risk of liver cancer, but the results are inconsistent. We present a meta-analysis of observational studies to explore this association.

Methods

We identified studies by a literature search of PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and relevant conference proceedings up to March 2014. A random-effects model was used to generate pooled multivariable adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Between-study heterogeneity was assessed using Cochran's Q statistic and the I2.

Results

Fifteen studies (five case-control and 10 cohort studies) were included in this analysis. There were 4,487,662 subjects in tot

SUBMITTER: Liu Y 

PROVIDER: S-EPMC4188756 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature