Efficacy of cardiac resynchronization in acutely infarcted canine hearts with electromechanical dyssynchrony.

ABSTRACT:

Background

Patients with acute myocardial infarction (MI), left bundle branch block (LBBB), and marked left ventricular (LV) decompensation suffer from nearly 50% early mortality. Whether cardiac resynchronization therapy (CRT) improves hemodynamic status in this condition is unknown. We tested CRT in this setting by using a canine model of delayed lateral wall (LW) activation combined with 2 hours of coronary artery occlusion-reperfusion.

Objective

This study aimed to evaluate the acute hemodynamic effects of CRT during and immediately after MI.

Methods

Adult dogs (n = 8) underwent open-chest 2-hour mid-left anterior descending artery occlusion followed by 1-hour reperfusion. Four pacing modes were compared: right atrial pacing, pseudo-left bundle block (right ventri

SUBMITTER: Chow GV 

PROVIDER: S-EPMC4188793 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature