Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results.

ABSTRACT:

Background

Candidate gene studies have been a key approach to the genetics of schizophrenia (SCZ). However, the results of these studies are confusing and no genes have been unequivocally implicated. The hypothesis-driven candidate gene literature can be appraised by comparison with the results of genome-wide association studies (GWAS).

Method

We describe the characteristics of hypothesis-driven candidate gene studies from the SZGene database, and use pathway analysis to compare hypothesis-driven candidate genes with GWAS results from the International Schizophrenia Consortium (ISC).

Results

SZGene contained 732 autosomal genes evaluated in 1374 studies. These genes had poor statistical power to detect genetic effects typical for human diseases, assessed only 3.7% of

SUBMITTER: Collins AL 

PROVIDER: S-EPMC4188923 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature