Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis.

ABSTRACT: Hookworms infect more than 700 million people worldwide and cause more morbidity than most other human parasitic infections. Nippostrongylus brasiliensis (the rat hookworm) has been used as an experimental model for human hookworm because of its similar life cycle and ease of maintenance in laboratory rodents. Adult N. brasiliensis, like the human hookworm, lives in the intestine of the host and releases excretory/secretory products (ESP), which represent the major host-parasite interface. We performed a comparative proteomic analysis of infective larval (L3) and adult worm stages of N. brasiliensis to gain insights into the molecular bases of host-parasite relationships and determine whether N. brasiliensis could indeed serve as an appropriate model for studying human hookworm infections.

SUBMITTER: Sotillo J 

PROVIDER: S-EPMC4188999 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature