Down regulation of Thrombospondin2 predicts poor prognosis in patients with gastric cancer.

ABSTRACT:

Background

Thrombospondins (THBSs) are a family of multidomain and secreted matricellular Ca(2+)-binding glycoproteins which has at least five members encoded by independent genes. As a THBSs family member, Thrombospondin2 (THBS2) has been reported to regulate angiogenesis. Nevertheless, the functions and clinical significance of THBS2 still remains unclear in gastric cancer.

Methods

The mRNA and protein expression levels of THBS2 were assessed in 14 paired of gastric cancer specimens and corresponding normal mucosas using quantitative real-time PCR and western blot analysis. Immunohistochemistry of THBS2 and CD34 on population-based tissue microarrays consisting of 129 gastric cancer cases were used to evaluate the prognostic significance of THBS2 and microvessel density (M

SUBMITTER: Sun R 

PROVIDER: S-EPMC4189190 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature