Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions.

ABSTRACT:

Background

Colorectal cancer is the second leading cause of cancer death in the United States, with over 50,000 deaths estimated in 2014. Molecular profiling for somatic mutations that predict absence of response to anti-EGFR therapy has become standard practice in the treatment of metastatic colorectal cancer; however, the quantity and type of tissue available for testing is frequently limited. Further, the degree to which the primary tumor is a faithful representation of metastatic disease has been questioned. As next-generation sequencing technology becomes more widely available for clinical use and additional molecularly targeted agents are considered as treatment options in colorectal cancer, it is important to characterize the extent of tumor heterogeneity between primary and

SUBMITTER: Brannon AR 

PROVIDER: S-EPMC4189196 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature