An open-source toolbox for automated phenotyping of mice in behavioral tasks.

ABSTRACT: Classifying behavior patterns in mouse models of neurological, psychiatric and neurodevelopmental disorders is critical for understanding disease causality and treatment. However, complete characterization of behavior is time-intensive, prone to subjective scoring, and often requires specialized equipment. Although several reports describe automated home-cage monitoring and individual task scoring methods, we report the first open source, comprehensive toolbox for automating the scoring of several common behavior tasks used by the neuroscience community. We show this new toolbox is robust and achieves equal or better consistency when compared to manual scoring methods. We use this toolbox to study the alterations in behavior that occur following blast-induced traumatic brain injury (bTBI),

SUBMITTER: Patel TP 

PROVIDER: S-EPMC4189437 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature