Discovery of prognostic factors for diagnosis and treatment of epithelial-derived ovarian cancer from laying hens.

ABSTRACT: Ovarian cancer is a lethal gynecological cancer causing cancer-related deaths in women worldwide. It is difficult to diagnosis at an early stage when more than 90% patients can be cured because of lack of specific symptoms and early detection markers. Most of malignant ovarian tumors are originated from the germinal epithelium of the ovary. For investigation with animal models of epithelial-derived ovarian cancer (EOC), laying hens are the most relevant animal models because they spontaneously develop EOC as occurs in women through ovulating almost every day. As in women, EOC in the hen is age-related and grossly and histologically similar to that in women. However, domesticated animals are inappropriate for research human EOC due to multiple pregnancies and lactating or seasonally anestro

SUBMITTER: Lim W 

PROVIDER: S-EPMC4189469 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature