Correlation of PCSK9 gene polymorphism with cerebral ischemic stroke in Xinjiang Han and Uygur populations.

ABSTRACT:

Background

Cerebral ischemic stroke (CIS) is a major cause of morbidity and mortality. Its main pathological basis is atherosclerosis (AS); in turn, the main risk factor in AS is dyslipidemia. Human proprotein convertase subtilisin/kexin9 (PCSK9) plays a key role in regulating plasma low-density lipoprotein (LDL) cholesterol levels. We sought to assess the association between PCSK9 and CIS in Chinese Han and Uygur populations.

Material and methods

We selected 408 CIS patients and 348 control subjects and used a single-base terminal extension (SNaPshot) method to detect the genotypes of the 20 single-nucleotide polymorphisms (SNPs) in PCSK9.

Results

Distribution of SNP8 (rs529787) genotypes showed a significant difference between CIS and control participants (P=0.049).

SUBMITTER: Han D 

PROVIDER: S-EPMC4189717 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature