Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies.

ABSTRACT:

Background

The epilepsies are a clinically heterogeneous group of neurological disorders. Despite strong evidence for heritability, genome-wide association studies have had little success in identification of risk loci associated with epilepsy, probably because of relatively small sample sizes and insufficient power. We aimed to identify risk loci through meta-analyses of genome-wide association studies for all epilepsy and the two largest clinical subtypes (genetic generalised epilepsy and focal epilepsy).

Methods

We combined genome-wide association data from 12 cohorts of individuals with epilepsy and controls from population-based datasets. Controls were ethnically matched with cases. We phenotyped individuals with epilepsy into categories of genetic generalised epilepsy,

SUBMITTER: International League Against Epilepsy Consortium on Complex Epilepsies. Electronic address: [e-mail] 

PROVIDER: S-EPMC4189926 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature