Pharmacogenetic effects of 'candidate gene complexes' on stroke in the GenHAT study.

ABSTRACT:

Objective

The aim of this study was to investigate whether there is a genotype-by-treatment interaction in patients experiencing stroke and treated with one of three antihypertensive drugs, that is chlorthalidone, amlodipine, or lisinopril.

Participants and methods

A population of 436 African Americans and 539 whites who had experienced stroke in the GenHAT study were genotyped for 768 single nucleotide polymorphisms (SNPs) in 280 candidate genes. To detect a genotype-by-treatment interaction, we used the Pearson's χ-test to assess whether the genotype frequencies differed at the single SNP level for the three drug treatment groups. From these single SNP analyses, we derived a summary statistic for the degree of association at the gene and gene complex levels. This was done

SUBMITTER: Sorensen IF 

PROVIDER: S-EPMC4189974 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature