Single nucleotide polymorphisms in AREG and EREG are prognostic biomarkers in locally advanced gastric cancer patients after surgery with curative intent.

ABSTRACT:

Objective

Amphiregulin (AREG) and epiregulin (EREG) are important ligands to the epithelial growth factor receptor, which is involved in the regulation of progression and stemness in gastric cancer (GC). This study investigated whether frequent single nucleotide polymorphisms (SNPs) in genes of AREG and EREG are associated with recurrence-free survival and overall survival in patients with locally advanced GC.

Methods

SNPs with a minor allele frequency of at least 10% were analyzed using direct DNA sequencing in two independent study populations.

Results

The minor allele of AREG rs1615111 was associated with a significantly higher 3-year recurrence rate and lower 3-year survival rate [hazard ratio (HR)=2.21 and 2.35, respectively] compared with patients homozygous for

SUBMITTER: Wakatsuki T 

PROVIDER: S-EPMC4190127 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature