Role of IL-4 gene polymorphisms in HBV-related hepatocellular carcinoma in a Chinese population.

ABSTRACT:

Background

Interleukin-4 (IL-4) is best known as an important mediator and modulator of immune and inflammatory responses. Hepatocellular carcinoma (HCC) is a typical inflammation-related cancer, and genetic variations in the IL-4 gene may be associated with the risk of hepatitis B virus (HBV)-related HCC. However, few studies have been conducted on their association.

Objectives

To clarify the effects of IL-4 gene polymorphisms on the risk of HBV-related HCC, two common variants, -590C/T (rs2243250) and -33C/T (rs2070874), and their relationship with HBV-related disease risk were investigated in a Chinese population.

Methods

IL-4 -590C/T and -33C/T polymorphisms were examined in 154 patients with HBV-related HCC, 62 patients with HBV-induced liver cirrhosis (LC), 129

SUBMITTER: Lu Y 

PROVIDER: S-EPMC4190355 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature