MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly.

ABSTRACT: Although much is known about how individual cytoskeletal systems contribute to physiological processes such as cell migration and branching morphogenesis, little is known about how these different systems actively coordinate their functions after polymerization. Here we show that both fibroblasts and developing glands reciprocally coordinate levels of cellular contractility and microtubule acetylation. We find that this balance is achieved by interaction of the myosin phosphatase target subunit of myosin phosphatase with either myosin light chain or HDAC6, a microtubule deacetylase. This balance of contractility and microtubule acetylation controls progression of adhesion maturation by regulating surface density of α5β1 integrin and fibronectin. Thus, we propose that a homeostatic balance

SUBMITTER: Joo EE 

PROVIDER: S-EPMC4190669 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature