Topographic cell instructive patterns to control cell adhesion, polarization and migration.

ABSTRACT: Topographic patterns are known to affect cellular processes such as adhesion, migration and differentiation. However, the optimal way to deliver topographic signals to provide cells with precise instructions has not been defined yet. In this work, we hypothesize that topographic patterns may be able to control the sensing and adhesion machinery of cells when their interval features are tuned on the characteristic lengths of filopodial probing and focal adhesions (FAs). Features separated by distance beyond the length of filopodia cannot be readily perceived; therefore, the formation of new adhesions is discouraged. If, however, topographic features are separated by a distance within the reach of filopodia extension, cells can establish contact between adjacent topographic islands. In the l

SUBMITTER: Ventre M 

PROVIDER: S-EPMC4191099 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature