Ontology highlight
ABSTRACT:
SUBMITTER: Smith SC
PROVIDER: S-EPMC4191414 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Nucleic acids research 20140912 18
The Replication Stress Response (RSR) is a signaling network that recognizes challenges to DNA replication and coordinates diverse DNA repair and cell-cycle checkpoint pathways. Gemcitabine is a nucleoside analogue that causes cytotoxicity by inducing DNA replication blocks. Using a synthetic lethal screen of a RNAi library of nuclear enzymes to identify genes that when silenced cause gemcitabine sensitization or resistance in human triple-negative breast cancer cells, we identified NIMA (never ...[more]