Ontology highlight
ABSTRACT:
SUBMITTER: Liu YL
PROVIDER: S-EPMC4191686 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Aging cell 20090316 4
Exposure to sub-lethal levels of stress, or hormesis, was a means to induce longevity. By screening for mutations that enhance resistance to multiple stresses, we identified multiple alleles of alpha-1,2-mannosidase I (mas1) which, in addition to promoting stress resistance, also extended longevity. Longevity enhancement is also observed when mas1 expression is reduced via RNA interference in both Drosophila melanogaster and Caenorhabditis elegans. The screen also identified Edem1 (Edm1), a gene ...[more]