Lag in maturation of the brain's intrinsic functional architecture in attention-deficit/hyperactivity disorder.

ABSTRACT: Attention-deficit/hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood, and there is great interest in understanding its neurobiological basis. A prominent neurodevelopmental hypothesis proposes that ADHD involves a lag in brain maturation. Previous work has found support for this hypothesis, but examinations have been limited to structural features of the brain (e.g., gray matter volume or cortical thickness). More recently, a growing body of work demonstrates that the brain is functionally organized into a number of large-scale networks, and the connections within and between these networks exhibit characteristic patterns of maturation. In this study, we investigated whether individuals with ADHD (age 7.2-21.8 y) exhibit a lag in maturation of the bra

SUBMITTER: Sripada CS 

PROVIDER: S-EPMC4191792 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature