An intervention to support HIV preexposure prophylaxis adherence in HIV-serodiscordant couples in Uganda.

ABSTRACT:

Background

Daily preexposure prophylaxis (PrEP) is an effective HIV prevention strategy, but adherence is required for maximum benefit. To date, there are no empirically supported PrEP adherence interventions. This article describes the process of developing a PrEP adherence intervention and presents results on its impact on adherence.

Methods

The Partners PrEP Study was a placebo-controlled efficacy trial of daily oral tenofovir and emtricitabine/tenofovir PrEP among uninfected members of HIV-serodiscordant couples. An ancillary adherence study was conducted at 3 study sites in Uganda. Participants with <80% adherence as measured by unannounced pill count received an additional adherence counseling intervention based on Lifesteps, an evidence-based HIV treatment adherence i

SUBMITTER: Psaros C 

PROVIDER: S-EPMC4191829 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature